Molecular Colonoscopy & Multi-omics.

We will implement molecular colonoscopy, a cutting edge molecular risk assessment tool, for estimating the risk of healthy-appearing individuals for colorectal neoplasia. Using this tool, we will identify biomarkers predicting the relative probability of each individual for colorectal neoplasias. In parallel, we will implement established translational protocols using Drosophila to …

Human Genes, Microbes and Environment in CRC and IBD

Host-microbe interactions control colonic dysbiosis, aberrant immune responses and intestinal epithelium damage, potentially predisposing for colorectal cancer (CRC). Most studies on CRC focus on tumor genetics, while more recently intestinal microbiota are studied in relation to health and disease. Nevertheless, neither tumor genetics nor microbiota composition alone may explain sporadic …