The balance between pro-tumorigenic and anti-tumor inflammatory networks in the tumor environment might define the progress CRC.

Chronic inflammation is one of the critical factors implicated in sporadic CRC initiation and progression. Inflammation mediators, such as cytokines, indicate pivotal role in CRC initiation or suppression. The cytokine expression pattern of each individual in the intestinal microenvironment is an indicative factor of CRC appearance prognosis and the balance between pro-tumorigenic and anti-tumorigenic cytokines is a predicting factor of how prone each subject is to CRC appearance.